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Collectively, to better understand the therapeutic potential of NADPH metabolism, more preclinical and clinical studies should be implemented to address these difficulties, and combined approaches with immunotherapy and/or chemotherapeutics should be pursued as the best strategies because of their synergistic effects

However, excessive exercise without proper recovery can paradoxically increase ROS, highlighting the need for balanced regimens (Margaritelis et al., 2018)

The research team led by Figure 3E, confirming the superior pro-angiogenic capacity of the combined therapy

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