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KPV also acts through a receptor-independent mechanism: direct suppression of NF-B nuclear translocation, the master transcription factor for inflammatory gene expression

Decreased or diminished expression and/or function of Cxs has been observed in most tumor cell lines and in solid tissue tumors, including melanomas

Its flagged, or maybe it sits near the top of the range

By synergistically combining these two mechanisms, the system elevates the ability of COFs to induce immunogenic cell death to a new level, achieving an effect greater than the sum of its parts