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A., de Vera, M

In a rat model of intervertebral disc degeneration, MOTS-c injection preserved disc height (82.4% versus 58.7% in the untreated group), restored MRI signals indicating improved disc hydration, and reduced histological degeneration scores by 44% compared to untreated controls

Challenging clinical cases: What factors should guide your choice of therapy

Characteristic clinical manifestations included early infantile onset hypotonia, swallowing, speech difficulties, respiratory insufficiencies, and a fatal course (seven died within the first year of life and one at age 16 years)