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Pharmacokinetics and drug-likeness of antidiabetic flavonoids: Molecular docking and DFT study

It is well known that CNS trauma and infection are accompanied by widespread inflammation in the brain and resident glial cells, including astrocytes and microglia, play a key role in the initiation and propagation of this response (Corrigan et al., 2016)

Similar to PROTAC 51 , PROTAC 52 exhibits robust cytotoxic activity against several FLT3-ITD mutant AML cells (IC 50 = 1.66 nM) by inducing a marked UPS-dependent degradation of the FLT3-ITD protein (DC 50 = 41.35 nM)