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Symptoms of severe vitamin B12 deficiency can include visual disturbances, severe joint pain, paresthesia (tingling in the hands and feet), memory problems, depression, anxiety, poor muscle function, ataxia (impaired balance and coordination), changes in reflexes and even infertility

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Notably, addition of BHB was able to increase the numbers and functionality of cultured human CD4 + T cells, even in the absence of amino acids (Fig