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The first was a Finnish cohort with a sample size of 224,737, including ILC data, which allowed us to replicate our primary findings using a two-sample MR analysis [27]

Science (2011) 334:67883

Mechanistically, T3 can activate tumor suppressor LKB1/AMPK/Raptor signaling as well as oncogenic PI3K/Akt signaling in HCC

Patients with stage 4 and 5 CKD with kidney failure have some of the highest rates of adverse outcomes (including premature mortality) but are often excluded in clinical trials, with even lower enrollment of those patients on dialysis or those who have received a kidney transplantation