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Today, liver transplantation remains the only curative option for Wilson disease, but it is associated with immunosuppression for life and significant morbidity.

doi: 10.1038/bjc.2016.455 116 HuangJYChengYJLinYPLinHCSuCCJulianoRet al

In another hand, while most reports appear to implicate IGF-I as a potential mediator of pathological changes in the diabetic kidney[364, 365], IGF-I is also protective against oxidative stress and apoptosis induced by high levels of glucose in cultured mesangial cells

Immunofluorescence The 6.5 10 4 hDP cells were transferred into a 35-mm confocal dishes (SPL life sciences, Korea) and then exposed to NTAPP 24 h after seeding