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Myofibroblasts, the key effector cells in fibrosis, arise from fibroblasts, pericytes, endothelial cells, or epithelial cells via epithelialmesenchymal transition (EMT) under stimulation by transforming growth factor (TGF) -, clotting factors, and mechanical stress [11, 29, 34, 36]

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The copper component is not merely a passive constituent but actively contributes to the biological effect