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Cong et al found that in mice, AS-IV activates the SIRT1/PGC-1/FNDC5 signaling pathway, therefore effectively inhibiting atrial fibrosis, atrial fibrillation and oxidative stress induced by angiotensin II (55)

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Several lines of evidence show that ApoE4-mediated astrocytic protein changes have a multitude of damaging effects that include reduced spine density and shorter spine length (Nwabuisi-Heath et al., 2014), increased tau-mediated synaptic loss (Wang et al., 2021), reduced expression of postsynaptic density protein 95 (PSD-95, also known as synapse-associated protein 90

and its lipid-lowering activity in vitro