glutathione role in cells Depletion and Stalwart Anticancer Activity of Metallotherapeutics Inducing Programmed Cell Death: Opening a New Window for Cancer Therapy Sustained dysregulation of iron and

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Liu X, Xia T, Fang Y, et al

1 H NMR (400 MHz, DMSO- d 6 ) 12.43 (s, 1H), 11.13 (s, 1H), 9.77 (s, 1H), 7.78 (dt, J = 16.4, 8.0 Hz, 2H), 7.64 (d, J = 6.9 Hz, 1H), 7.41 (d, J = 3.5 Hz, 1H), 6.73 (s, 1H), 5.12 (dd, J = 12.8, 5.4 Hz, 1H), 4.07 (s, 2H), 3.54 (d, J = 11.8 Hz, 2H), 3.14 (t, J = 7.2 Hz, 2H), 3.02 (d, J = 6.3 Hz, 2H), 2.952.83 (m, 3H), 2.73 (dd, J = 24.9, 13.0 Hz, 1H), 2.60 (d, J = 19.5 Hz, 1H), 2.552.52 (m, 1H), 2.05 (dd, J = 13.9, 9.7 Hz, 3H), 1.91 (dd, J = 23.5, 11.9 Hz, 2H), 1.68 (d, J = 6.9 Hz, 4H), 1.46 (s, 2H), 1.32 (s, 6H), 1.19 (s, 9H)

Each of six subunits is structured as a four-helix bundle, with the helices arranged in an alternating up-down pattern