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With the increasing popularity of MCT supplementation and growing public awareness of its potential cognition-enhancing effects, more research is needed to clarify the long-term effects of MCT supplementation on cardiovascular and metabolic health, as well as how MCTs are being used outside clinical settings

In the present study, we show that depletion of cellular GSH by BSO sensitizes antihormone-resistant MCF-7:2A cells to estradiol-induced apoptosis that is mediated, in part, by the mitochondrial pathway and also activation of the c-Jun N-terminal kinase (JNK) signaling pathway

However, there is compelling evidence that caspase-3 and caspase-8 are downstream effectors of the Fas cell death signaling pathway, indicating their importance for extrinsic Fas-mediated eryptosis (see the Extrinsic Fas-mediated eryptosis section) [130, 136]

62 IhalinR.EneslattK.AsikainenS