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Collectively, this work proposes an LDH-based strategy that concurrently alleviates pathological acidosis, oxidative stress, mitochondrial dysfunction, and macrophage polarization imbalance, providing a potential nanotherapeutic approach for OA management

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H., Kolobova, I., Niederhausen, M., Janowsky, J

Berberine improves tumor immunity Berberine has indicated significant immunomodulatory actions in regulating tumor microenvironment by modulating various immune cells, inflammatory mediators, and immune checkpoint pathways [203]