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8 BarolloS.BertazzaL.Watutantrige-FernandoS.CensiS.CavedonE.GaluppiniF.et al (2016)

Musculoskeletal manifestations of HSDs include: macro- or micro-instability, chronic musculoskeletal pain, disturbed proprioception (poor joint awareness) and muscle weakness, degenerative joint or bone disease, and other musculoskeletal traits such as pes planus foot type, scoliosis, kyphotic-lordotic spinal shape, valgus deformity of elbows, knees, hindfeet and halluces

However, if the FDA ultimately reclassifies them, clinicians would have discretion to write prescriptions outside of those narrow indications

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