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2002 Dec;140(6):380- 1

Furthermore, HIF-1 signaling promotes glutathione biosynthesis to bolster cellular antioxidant defense capacity, establishing a regulatory feedback loop between oxidative stress and hypoxic adaptation

Vaccines can be combined with adjuvants, such as drugs like AMG510 (Sotorasib), to create a stronger immune response in the immunosuppressive tumour microenvironment ( Preclinical models in mimic of TNBC Preclinical models that accurately mimic TNBC aetiology are vital for assessing new therapy options and identifying long-term benefits for patients ( in vitro and in vivo ( Figure 10 ) ( Figure 10 Novel breast cancer drugs in use or in clinical trials for the treatment of TNBC Numerous possible agents are undergoing various phases of investigation and advancement

SCD is characterized by intravascular hemolysis, driven by the polymerization of mutated hemoglobin within red blood cells (RBCs), leading to vascular inflammation, organ damage, and heme toxicity