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Angelidis, I

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The reality check: the FDA does not consider it a legal cosmetic or dietary ingredient, and there is real concern that long-term use raises the risk of melanoma (skin cancer) the opposite of what most people assume a tan in a vial would do for skin safety (WebMD)

Those facts were confirmed in animal models of IGF-I deficiency as they often exhibit increased ROS production and decreased NO bioavailability, mimicking the vascular aging phenotype[294]