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Challenges in the diagnosis of vitamin B 12 deficiency Subclinical B 12 deficiency is asymptomatic The diagnosis and management of subclinical vitamin B 12 deficiency, which is defined as a total serum B 12 concentration of 150249 pmol/L(Carmel, 2012, 2013) is a matter of great interest, due to its much higher prevalence (up to 40% of the population in western countries) compared to clinical deficiency (Carmel, 2012, 2013)

In our review, some ( Patients with vitamin B12 deficiency who are symptomatic have severe neurological deficits or have critically low blood levels of vitamin B12 should be treated with IM administration

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(2003) : Demonstrated telomerase activation and telomere elongation in human fetal lung fibroblasts treated with epitalon