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Smith GS, Oeltzschner G, Gould NF, Leoutsakos JS, Nassery N, Joo JH et al

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70,71 By mitigating the systemic and cellular hallmarks of aging, TCM may create a less favorable environment for ferroptosis initiation, thereby exerting a protective effect against age-dependent neurodegenerative processes like AD

Protein patched homolog 1 (PTCH1) plays the tumor-conquering action which encodes a protein receptor termed Sonic Hedgehog (SHH), which causes the loss of PTCH1 functionalities that impacts on working of G-Protein coupled receptor as decreasing the suppression of intracellular signaling which Smoothened (SMO) G-Protein coupled receptor