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-Aminoisobutyric acid, a natural non-protein -amino acid, activates the LKB1/AMPK/SIRT1 axis, promotes NF-B p65 phosphorylation and nuclear translocation, delays IB phosphorylation and degradation, alleviates VSMC inflammation, and activates Nrf2 to relieve oxidative stress, collectively inhibiting VSMC proliferation and migration [221]

Ang-2 up-regulation has been noticed in multiple types of tumors and is likely involved in resistance versus anti-VEGF therapy [88, 89]

F., Nilsson, M., Eriksson, P

Stimulation of cells expressing both c-MET and EGFR with EGF resulted in phosphorylation of c-MET, and stimulation with ligands for both receptors resulted in synergistic activation of downstream modulators, indicating mutual activation of these two pathways [Puri and Salgia, 2008]