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The precise mechanisms underlying MSC homing and localization in the kidney are still being studied, but it is thought to be related to interactions with adhesion molecules, chemokines, and cytokines present in the injured tissue

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3-D cell discs were formed by culturing vascular smooth muscle cells in collagen first and then 3-D discs with similar size were incubated in different media for 24 h

While oral bioavailability is lower than subcutaneous administration, these studies established that even high oral doses maintained excellent safety profiles, though higher doses (54 mg) were associated with increased gastrointestinal discomfort