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It has been previously suggested that the accumulation of GSSG may exert cytotoxic effects due to its propensity to form disulfides with intracellular proteins, which leads to their inactivation (Forman et al., 2009

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AF symptoms (virtually by definition) involve [11] A supraventricular tachyarrhythmia with uncoordinated atrial electrical activation and consequently ineffective atrial contraction