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The duplexed region can be connected by a linker, e.g., a nucleotide linker, e.g., 3, 4, 5, or 6 dTs, e.g., modified dTs

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Damage to the mitochondrial membrane by excessive ROS can further exacerbate ROS generation (110) ( Figure 2a )

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Besides, secretion of TNF- by macrophages is inhibited by acidic pH (112)

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