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The review also documented how GCL expression is transcriptionally upregulated by electrophiles through antioxidant response elements (ARE/EpRE) in the GCLC and GCLM promoters establishing the Nrf2/ARE pathway as the master regulator of GSH biosynthetic capacity under stress conditions

10.1016/j.cbi.2024.111004 51 HuZ.WangL.HanY.LiF.ZhengA.XuY.et al (2018)

Haferlach C, Grossmann V, Kohlmann A, Schindela S, Kern W, Schnittger S, et al

For instance, B vitamins, vitamin C, magnesium, and amino acids are crucial in cellular metabolism and can enhance the production of ATP, the primary energy molecule, which may help alleviate fatigue in our patients