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Moreover, oxidative damage to mitochondrial DNA (mtDNA) results in the release of mtDNA into the cytosol, where it triggers Toll-like receptor 9 (TLR9) and inflammasome activation, leading to further production of pro-inflammatory cytokines and recruitment of immune cells 67

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In addition, recent studies have shown the pharmacological potential of taurine against neurodevelopmental disorders

Still, the exosome delivery methods should be able to move quickly to clinical trials because they are well-tolerated by living things (128), so, drug conjugated exosomes for deliveries over the BBB are increasingly explored for ALS and other neurological illnesses (129)