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In Huntingtons disease (HD), oxidative stress plays a significant role in the neurodegenerative process

Lucentis This drug was approved by the FDA in June 2006 for the treatment of wet AMD

Neurotoxicity of manganese via ferroptosis induced by redox imbalance and iron overload

Thus, as far as mitochondrial oxidative stress homeostasis is concerned, mGSH is a vital factor maintaining mitochondrial function, controlling cell survival/death, and its depletion causes cell damage and facilitates cell death [57, 59]