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10.1016/j.neuint.2010.01.006 53

Marked reduction of the Cu/Zn superoxide dismutase polypeptide in a case of familial amyotrophic lateral sclerosis with the homozygous mutation

Studies have suggested that the sleep-wake cycle is profoundly affected with age marked by insomnia, sleep fragmentation, and daytime sleepiness that trigger the neurodegeneration and significantly affects the mental health and longevity in elderly subjects (Casagrande et al., 2022