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The post-mortem studies on idiopathic ASD individuals have revealed that genes involved in activated astrocytes and microglia are upregulated in the cortex of the brain and to a lesser extent in the cerebellum [198, 199]

GSH also plays a role in metabolism of various drugs, such as opiates

However, in most cases, HIF-1 is believed to have a tendency to facilitate the growth of cancer cells and its inhibitory effect can be offset by other compensatory pathways in tumor cells