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Targeting TXNRD1 maintains efficacy of first-line therapy in vivo SCLC patients typically show high initial response rates to cisplatin-based chemotherapy, followed by relapse shortly after completing first-line therapy

Kysel P, Haluzkov D, Dolealov RP, Lakov I, Lacinov Z, Kasperov BJ, et al

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These compounds aim to reduce inflammation, restore tissue homeostasis, and promote tissue regeneration by modulating the environment surrounding senescent cells.130 Unlike senolytics, which focus on cell death, senomorphics maintain the senescent cells presence but modify its behavior, particularly the pro-inflammatory and tissue-damaging components of the SASP.129 By reducing the detrimental effects of senescent cells, such as the SASP, senomorphics hold promise for treating a range of diseases, including cancer, neurodegenerative disorders, cardiovascular diseases, and metabolic syndromes.26 At the molecular level, senomorphics exert their effects primarily by modulating the signaling pathways that govern SASP production without inducing apoptosis in senescent cells