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Kratom has been shown to inhibit CYP enzymes in vitro , including CYP2D6 and CYP3A, which extensively metabolize several opioids and benzodiazepines

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6A), indicating the overlapping roles of these proteins in synaptic vesicle release and clathrin-mediated endocytosis

Studies demonstrate the peptide reduces neuronal death in cell culture models of oxidative stress and glutamate excitotoxicity, with protective effects observed at the same ultralow concentrations that produce cognitive enhancement