glutathione hydrogen peroxide reaction Frontiers Reactive Oxygen Species and Cellular

Key highlights include a systematic delineation of both core and emerging ferroptosis-regulatory networks, a detailed analysis of the pathological contributions of ferroptosis across distinct CVDs, and a critical evaluation of evolving therapeutic strategies ranging from small-molecule inhibitors to advanced nanomedicine-based approaches

Disruption of redox homeostasis impairs DC maturation and reduces inflammatory cytokine production, contributing to severe HCC progression [174]

While macrophages and other immune cells can partially clear these ROS, the excessive ROS burden surpasses the clearance capacity of immune cells, allowing residual ROS to further activate necroptosis through positive feedback mechanisms

Furthermore, there remains controversy regarding the biological functions of mitochondrial transfer and reprogramming