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Nanomedicine 12:16311645

On the one hand, Nrf2 and HO-1 are significantly upregulated in mouse colitis, exerting anti-inflammatory and antioxidant effects [264, 287]

doi: 10.1126/science.abg3055

Purines like microbiome-derived hypoxanthine allow efficient biosynthesis of nucleotides and IECs can improve their energy balance by preferentially salvaging exogenous purines for ATP biosynthesis 123