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MillerYIChoiSHWiesnerPFangLHHarkewiczRHartvigsenKet al

The catalytic activity of PRDXs is crucially dependent on a conserved peroxidatic Cys (Cp) residue contained within a universally conserved Pxxx(T/S)xxC active-site motif in the amino-terminal portion of the protein (17), which corresponds to Cys-47 in yeast cytosolic thioredoxin peroxidase I (cTPx I) (15)