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For instance, CC chemokine receptor-2, vascular cell adhesion molecule-2, and scavenger receptors-A, increase the expression level of PD-L1 that activates PD-1 IC receptor (this restricts the activity of cytotoxic T-cells and further strength the cold tumor environment of GBM) and secretory protein rich in cysteine (SPARC), etc

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The connections between nearby pericytes must be weakened, and the basement membrane around them must be deteriorated