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Our team has been developing methods for systematic and programmable functionalization of heteroarenes, which are essential building blocks in medicinal chemistry, including indoles, pyrroles, pyrazoles, imidazoles, pyridines, and others 30,31,32,33,34,35,36

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Analysis of microvessel density (MVD) by CD31 and CD34 staining revealed that, in contrary to scr peptide, all treated doses of VGB4 resulted in a significant reduction in tumor vessels as compared to PBS-treated controls and the increase of the peptide dosage led to more striking reduction of tumor vessels (Fig