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it then activates the downstream MAPKK, and finally, MAPKK will activate the most downstream MAPK, this cascade reaction allows the signal to be amplified and transmitted within the cell (Jonak, 2002)

Taken together, these results demonstrate that pharmacological Ire1 inhibition suppresses lipid peroxidation induced by renal IRI in vivo, and through this mechanism alleviates renal damages caused by IRI