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Since the latter study had a placebo group which had redox and methylation biomarkers measured at the beginning and end of the intervention, we use this placebo group as a control group for all three studies in order to determine if the changes in redox and methylation metabolism were significant as a result of the three interventions

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In a related context, lipid-associated macrophages have been shown to undergo an inflammatory transition during human atherosclerosis, potentially contributing to ischemic heart disease, stroke, and peripheral arterial disease (Dib et al., 2023)

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