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Bone marrow adipocytes provide early sign for progression from MGUS to multiple myeloma

Although dryness (sicca) of the eyes and mouth are the classically described features, dryness of other mucosal surfaces and systemic manifestations, including fatigue and arthralgia, are common ( Digestive involvement is frequent in pSS, including autoimmune disorders, such as chronic atrophic gastritis, esophageal motility dysfunction, lymphocytic colitis, primary biliary cholangitis and autoimmune hepatitis ( pSS-related atrophic gastritis and associated PA may require parenteral or sublingual vitamin B12 supplementation (2)

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