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DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS-STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis

106,107 The interplay between oxidative stress and mtDNA damage is bidirectional

Treatment with lenalidomide, a known inhibitor of Ikaros 116 , significantly blocked IFN--mediated SerpinB2 downregulation (Fig