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35 Chronic toxicities are manifested as conditions that develop over extended periods from chronic exposure to relatively low concentrations (eg, sustained environmental exposure)

Under normal physiological circumstances, glutamate resides in presynaptic vesicles and is released into the synaptic cleft at high concentrations following neuronal depolarization 62

Note: Avoid mixing with high-concentration Vitamin C (L-ascorbic acid) or strong acids in the same step, as they may destabilize the copper ions

6,7 Implanted with a 22-gauge injector, the device releases dexamethasone in a biphasic manner over a 6-month period