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Mitophagy alterations in Alzheimer's disease are associated with granulovacuolar degeneration and early tau pathology

However, they are also the major site of reactive oxygen species (ROS) production due to electron leakage during oxidative phosphorylation

Minocycline reduces the lipopolysaccharide-induced inflammatory reaction, peroxynitrite-mediated nitration of proteins, disruption of the blood-brain barrier, and damage in the nigral dopaminergic system

The lateral root polysaccharides of Aconitum carmichaelii (RFP) had the cytotoxicity effects on hydrogen peroxide-induced injury and prohibited apoptosis in vitro, by contrast, RFP attenuated cisplatin-induced acute kidney injury in vivo through inhibition of ferroptosis with the increased levels of GSH and GPX4, the decreased levels of MDA and 4-hydroxynonenal as well as the reduced lipid peroxidation (Tian et al., 2022)