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Physicians may find this 7-point care bundle useful to minimize the risk of future exacerbations and reduce morbidity and mortality

tophi Allopurinol (fully funded) is the first-line urate-lowering medicine

doi: 10.1042/BST20221066 175 Falco-PiresICastro-ChavesPMiranda-SilvaDLourenoAPLeite-MoreiraAF

This outcome results from increased activities of snail proteins, whose expression levels are up-regulated in a lactate dose-dependent manner and via the TGF-1/SMAD axis