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Thus, neuroprotection, a currently elusive goal, may be achieved via parallel suppression of pressure sensing in the anterior eye, retinal neurons, blood vessels and glia in order to achieve normalization of neuron-glia-blood vessel interactions, and the attendant reduction in immune activation

Activation of alpha-1 leads to the (i) contraction of the iris dilator and Mullers muscles, leading to mydriasis and lid retraction, (ii) vasoconstriction causing the restriction of blood flow to the ciliary muscle, and (iii) reduced aqueous humor production [215]

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KDIGO (Kidney Disease: Improving Global Outcomes) CKD Work Group