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As part of the glutamate-glutamine cycle, astrocytes and oligodendrocytes take up the neurotransmitter glutamate released from neurons at synapses, metabolize it to glutamine using GLUL, and then export it back to neurons, where glutamine is converted back to glutamate using glutaminase (GLS)

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The lentivirus vector facilitates long-term gene expression in vivo at the expense of genomic integration