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Orlistat, phentermine/topiramate, naltrexone/bupropion, and the incretin-based drugs liraglutide and semaglutide, both GLP-1 receptor agonists (GLP-1RA), and tirzepatide, a biased dual GIP/GLP-1 receptor agonist, are currently both FDA and EMA approved for the management of non-syndromic obesity 10

When you combine them, you're tackling the issue from all angles, which often leads to a more complete and lasting recovery.

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Dosing considerations and safety monitoring Start conservatively: Begin with lower dosage ranges assessing tolerability before increasing