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Overall, LMMH emerged as a potent inducer of ICD in tumor cells, stimulating the enhanced release of HMGB1 and ATP to elicit adaptive anti-tumor immune responses, while the surface expression of CRT served as a eat me signal for antigen-presenting cells

These proteins are the components of larger complexes that possess the ability to bind to cargo sorting receptors (e.g., sortilin), molecular motors (e.g., kinesin and dynein), and other proteins required for trafficking, such as adaptor proteins and GTPases [73]

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He assumed the title role in Hedwig and The Angry Inch on Broadway on October 16, 2014, and performed the role until January 18, 2015