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10.1021/bi00250a043 25 SalinasG.SelkirkM

Yu G, Tian Q, Liu R, Wang Q, Wang JZ, Wang X

Indeed translocation of mTORC1 from the cytoplasm to the lysosome, a rich compartment in amino acids, is critical for mTORC1 activation ( per se is also able to regulate mTORC1 activity ( In brief, activation of the GCN2-ATF4 amino acid stress pathway and inhibition of protein synthesis through inhibition of mTORC1 demonstrates the strong proteogenic role played by cysteine in tumor cells