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Anti-inflammatory mechanisms Inflammation exacerbation is one of the characteristics of a series of diseases, including cardiovascular disease, diabetes, metabolic syndrome, rheumatoid arthritis, asthma, multiple sclerosis, and chronic pain, each of which would increase the risk of depression (Dantzer et al., 2008

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Consistent with a transport-independent function for GLUT3 in IL-4 signal transduction, the activation of p-STAT6 by IL-4 was not impaired in THP-1 cells treated with G3iA (Figure 4F and Supplemental Figure 7G)