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It has also been found that Keap1/Nrf2 mutation status predicts the risk of local recurrence after radiotherapy in NSCLC patients, and Keap1/Nrf2 mutant lung cancers may be radiotherapy resistant to radaition due to enhanced expression of ROS clearance and detoxification pathways (Umamaheswari et al., 2021)

Consequently, the GSH deprotonation step was considered non-rate-determining and thermodynamically favoured, leading us to use the GSH-thiolate as the starting point to compute the reaction mechanism for the conversion of flav-3-on-4-ol ( 7 ) into cyanidin ( 8-B4 ) in the wild-type enzyme and the C13S variant (Extended Data Fig

229 In osteoporosis, MSCs tend to favor adipogenic differentiation, which reduces bone formation and increases fat accumulation within the bone marrow, thereby exacerbating bone loss and increasing the risk of fractures

Results are shown as percentage of input