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Several MR antagonists (MRAs) have been developed over the years

Nevertheless, their clinical efficacy remains suboptimal, with a significant proportion of patients experiencing inadequate symptom relief and persistent functional impairment

While many lipid mediators result from these enzymatic processes, others such as phytoprostanes and aldehydes are created adventitiously when they encounter reactive oxygen species (ROS), and together, they are a redox regulatory network that couples ROS generation with subsequent stress signalling pathways in plants

Yin, M., Wheeler, M.D., Kono, H., Bradford, B.U., Gallucci, R.M., Luster, M.I