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H 2 S is synthesized by enzymatic processes involving cysteine and several enzymes, including cystathionine--synthase (CBS), cystathionine--lyase (CSE), cysteine aminotransferase (CAT), 3-mercaptopyruvate sulfurtransferase (3MST) and D-amino acid oxidase (DAO)

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-SMA, regulated by HDAC8, is highly expressed in myocardial fibrosis but less so in normal myocardium, suggesting an important role of HDAC8 in myocardial fibrosis (48)

Statistical analysis Statistical calculations were performed using the SPSS 13.0 for windows release computer program