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Am J Physiology-Endocrinology Metab

While it is generally understood that efflux pumps often play an important role in drug-resistant phenotypes, it remains poorly defined how molecular structure drives recognition by efflux pumps

In an autologous blood injection model of ICH, PDZ improves neurological recovery, an effect blocked by the Nrf2 inhibitor ML385, demonstrating that PPAR/Nrf2/GPX4 signaling underlies its protective mechanism (197)